Posted as a reply on another topic, but maybe worth it's own thread.
I did a spreadsheet where I mapped all the possible combos for my left hand - including with modifiers, etc, and ranked them by how difficult they were to physically do. For example, 'F' would be probably the easiest key to press.
Then I did another spreadsheet where I listed the tools I use in chief, and how frequently I use them. For example, I use 'open object' quite a bit. I also flip door swings, make dimensions, do point to point move, etc. I listed all these out, and ranked them by how often I use them. Remember to consider 3D views as well, and Layout - because you only get one set of hotkeys - they don't change based on the view.
Then I mapped the two lists together. It took a bit of work. But I almost never put my right hand on the keyboard, and I never have to look at the keyboard, so I'm blazing fast and it feels very natural.
It's a lot of work but was worth it for me.
Image below is from back in my SketchUp days, that's when I first did it. Also, I'm a Dvorak Keyboard guy so AOEUI are actually ASDFG on the left hand home row - but you get the idea.